Only includes biopsies with atypia, hyperplasia or LCIS. Incorporates features of Gail and Claus models, as well as height/BMI, use of HRT, cousins with breast cancer, and unaffected females. Proportional hazard model the relative risk based on personal factors is used to adjust the calculated genetic absolute risk.The following models are currently available in the latest release of Progeny: Tyrer-CuzickĪ breast cancer risk assessment tool incorporating family history, endogenous hormonal factors, benign disease, risk factors such as age and body mass index, and genetic factors (including BRCA) into a single statistical model.(Cancer Research Technology, 2016) Risk calculation results can be easily saved and timestamped within the database or saved as a pdf file at any time. Any missing or invalid data required to run these models are automatically identified for you. Progeny Clinical includes validated risk assessment models to calculate 5-year and lifetime cancer risk, as well as gene mutation probabilities for any member of a pedigree.
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